## Background: In this study we determined the consequence of the absence of each tnf receptor, tnfr1 or tnfr2, in the dextran sulfate sodium (dss) model of colitis. ## Methods: Wildtype (wt), tnfr1(-/-) and tnfr2(-/-) mice were fed 3% w/v dss in drinking water for 5 days followed by 2 (day 7) or
β¦ LIBER β¦
Role of TNFR-related 2 mediated immune responses in dextran sulfate sodium-induced inflammatory bowel disease
β Scribed by Woon-Ki Kim; Jin-Soo Park; Ok-Ju Sul; Jae-Hee Seo; Byum-Kyu Choi; Hee-Young Park; Anne M. Latour; Beverly H. Koller; Byoung S. Kwon; Choon-Soo Jeong
- Publisher
- Korean Society for Molecular and Cellular Biology
- Year
- 2011
- Tongue
- English
- Weight
- 1013 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1016-8478
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Background: Inflammatory bowel disease (IBD) is a critical public health issue; more and more people are affected, but treatment options remain limited. Complement activation and the anaphylatoxin C5a have been shown to play a role in IBD. In this study, mouse models of acute and chronic dextran sul