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Role of the Pim-1 kinase for vasculoproliferative processes in the context of the atherosclerotic plaque milieu

✍ Scribed by Manuela Willert; Ruth H. Strasser; Rüdiger C. Braun-Dullaeus


Book ID
116985105
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
50 KB
Volume
42
Category
Article
ISSN
0022-2828

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## Abstract Hypoxia‐inducible factor‐1 (HIF‐1) is a heterodimeric transcription factor that plays a major role in cellular adaptation to hypoxia. The mechanisms regulating HIF‐1 activity occurs at multiple levels __in vivo__. The HIF‐1α subunit is highly sensible to oxygen and is rapidly degraded b