Perturbation of hepatocyte growth regulation is associated with a number of liver diseases such as fibrosis and cancer. These diseases are mediated by a network of growth factors and cytokines that regulate the induction of hepatocyte proliferation and apoptosis. In this study, we have investigated
✦ LIBER ✦
Role of the Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways in the Secretion of Tumor Necrosis Factor-α and Interleukin-10 by the PPD Antigen ofMycobacterium tuberculosis
✍ Scribed by Saet-Byel Jung; Chang-Hwa Song; Chul-Su Yang; Su-Young Kim; Kil-Soo Lee; A-Rum Shin; Ji-Sook Lee; Hae Sung Nam; Hwa-Jung Kim; Jeong-Kyu Park; Tae-Hyun Paik; Eun-Kyeong Jo
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 530 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0271-9142
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## Abstract The proinflammatory cytokine tumor necrosis factor (TNF) α is mainly produced in cells from the monocyte/macrophage lineage. TNFα is also a key signaling molecule in the liver functioning as an important physiological and pathogenic mediator. In hepatocytes or human hepatoma cells TNFα