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ROLE OF THE NUCLEAR ACCUMULATION OF GSK-3BETA IN BLADDER CANCER MALIGNANT PHENOTYPE - POTENTIAL THERAPEUTIC TARGET

✍ Scribed by Naito, Sei; Bilim, Vladimir; Yuuki, Kaori; Ougolkov, Andrei V; Billadeau, Daniel D; Motoyama, Teiichi; Tomita, Yoshihiko

Book ID
122740372
Publisher
Lippincott Williams and Wilkins
Year
2009
Tongue
English
Weight
100 KB
Volume
181
Category
Article
ISSN
0022-5347

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Role of XIAP in the malignant phenotype
Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro
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## Abstract XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of __xiap__ AS PODN on the cell cycle and apoptosis of multidrug‐re