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Role of the Macrophage Inflammatory Protein-1α/CC Chemokine Receptor 5 Signaling Pathway in the Neuroinflammatory Response and Cognitive Deficits Induced by β-Amyloid Peptide

✍ Scribed by Giselle Fazzioni Passos; Cláudia Pinto Figueiredo; Rui Daniel Schröder Prediger; Pablo Pandolfo; Filipe Silveira Duarte; Rodrigo Medeiros; João B. Calixto

Book ID: 119980961
Publisher: American Society for Investigative Pathology
Year: 2009
Tongue: English
Weight: 1024 KB
Volume: 175
Category: Article
ISSN: 0002-9440
DOI: 10.2353/ajpath.2009.081113

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## Abstract The deposition of immune complexes induces an acute inflammatory response with tissue injury. Immune complex‐induced tissue injury is mediated by inflammatory cell infiltration that is highly regulated by multiple chemokines. To assess the role of the chemokine receptors CCR1 and CCR5,