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Role of the insulin-like growth factor system on an estrogen-dependent cancer phenotype in the MCF-7 human breast cancer cell line

✍ Scribed by Laurie M. Bradley; John F. Gierthy; Brian T. Pentecost

Book ID
116698129
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
649 KB
Volume
109
Category
Article
ISSN
0960-0760

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## Abstract The insulin‐like growth factors (IGFs) are potent mitogens for breast cancer cells and their activity is modulated by high affinity binding proteins (IGFBPs). We have recently shown that IGFBP‐1 purified from human amniotic fluid neutralizes IGF‐I‐dependent growth of MCF‐7 cells. In thi