ROLE OF THE CAMP DEPENDENT PROTEIN KINASES IN CELL PROLIFERATION: APPLICATION IN HUMAN PATHOLOGY
✍ Scribed by Sylvie, Tournier; Françoise, Raynaud; Danièle, Evain-Brion
- Book ID
- 123416780
- Publisher
- Portland Press
- Year
- 1992
- Tongue
- English
- Weight
- 128 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0248-4900
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The cell line A126-1B2 is a PC12-derived mutant that is resistant to the toxic effects of dibutyryladenosine 3'5'-cyclic monophosphate (dbcAMP) and is deficient in adenosine 3':5'-cyclic monophosphate (CAMP)-dependent protein kinase I1 (PKAII). This mutant formed neurites in response to nerve growth
Phorbol 12-myristate 13-acetate (PMA) has been shown to stimulate DNA synthesis and cell proliferation in a population of glial cells isolated from newborn rat brain. The non-tumor promoter 4a-phorbol l2,13-didecanoate (4a-PDD), on the other hand, was without an effect. The cultures treated with PMA