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Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

โœ Scribed by Daniel W Nebert; Amy L Roe; Matthew Z Dieter; Willy A Solis; Yi Yang; Timothy P Dalton


Book ID
113994642
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
920 KB
Volume
59
Category
Article
ISSN
0006-2952

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## Abstract Unconjugated bilirubin (UCB), the end product of heme catabolism, causes apoptosis in cells of the central nervous system, endothelial cells, and hepatotoma cells. However, the molecular mechanisms that contribute to UCB cytotoxicity remain unclear. The purpose of this study was to char