𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Role of the amino-terminal extrahelical region of type I collagen in directing the 4D overlap in fibrillogenesis

✍ Scribed by Donald L. Helseth Jr.; Joseph H. Lechner; Arthur Veis

Publisher
Wiley (John Wiley & Sons)
Year
1979
Tongue
English
Weight
624 KB
Volume
18
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The amino‐terminal telopeptide of the collagen α1(I) chain has a highly conserved sequence. This sequence was analyzed by the Chou‐Fasman criteria, and a folded β‐sheet conformation, including a β‐turn, was predicted. This folded “hairpin” region favors both ionic and hydrophobic intermolecular interactions with α1(I) chain residues 930–938 on a neighboring, end‐overlapped molecule. An end‐overlap interaction of this nature could direct the initial step in fibril formation. The predicted structure also places the potential crosslink‐forming lysyl residue, 9^N^, in a unique site at the β‐turn end of the telopeptide.

📜 SIMILAR VOLUMES

Role of the pro-α2(I) COOH-terminal regi
Role of the pro-α2(I) COOH-terminal region in assembly of type I collagen: Truncation of the last 10 amino acid residues of pro-α2(I) chain prevents assembly of type I collagen heterotrimer
✍ Ai-lee Lim; Sharon A. Doyle; Gary Balian; Barbara D. Smith 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 325 KB 👁 1 views

Procollagen (Type I) contains a noncollagenous COOH-terminal propeptide (C-propeptide) hypothesized to be important in directing chain association and alignment during assembly. We previously expressed human pro-␣2(I) cDNA in rat liver epithelial cells, W8, that produce only pro-␣1(I) trimer collage

Role of the pro-α2(I) COOH-terminal regi
Role of the pro-α2(I) COOH-terminal region in assembly of type I collagen: Disruption of two intramolecular disulfide bonds in pro-α2(I) blocks assembly of type I collagen
✍ Sharon A. Doyle; Barbara D. Smith 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 1 views

Collagen biosynthesis is a complex process that begins with the association of three procollagen chains. A series of conserved intra-and interchain disulfide bonds in the carboxyl-terminal region of the procollagen chains, or C-propeptide, has been hypothesized to play an important role in the nucle

The role of type I collagen in the regul
The role of type I collagen in the regulation of the osteoblast phenotype
✍ Songtao Shi; Martin Kirk; Arnold J. Kahn 📂 Article 📅 2009 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 716 KB

Evidence from a variety of sources indicates that the extracellular matrix forms an important part of a feedback loop governing the migration, proliferation, and differentiation of the cells that produce it. In keeping with this, we showed previously that the extracellular matrix of a multipotential

Mutation in the carboxy-terminal propept
Mutation in the carboxy-terminal propeptide of the proα1 (I) chain of type I collagen in a child with severe osteogenesis imperfecta (OI type III): Possible implications for protein folding
✍ Jane E. Oliver; Elizabeth M. Thompson; F. Michael Pope; Alan C. Nicholls 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 845 KB

A young girl presented with severe type 111 osteogenesis imperfecta; her otherwise healthy mother also had a mild connective tissue disorder with blue sclerae and recurrent joint dislocations. Skin fibroblast cultures from the child produced both normal and post-translationally overmodified type I c