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Role of the Alanine at Position 363 of Cytochrome P450 2B2 in Influencing the NADPH- and Hydroperoxide-Supported Activities

✍ Scribed by Imad H Hanna; John F Teiber; Kristin L Kokones; Paul F Hollenberg


Book ID
115566884
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
157 KB
Volume
350
Category
Article
ISSN
0003-9861

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πŸ“œ SIMILAR VOLUMES


Roles of phenylalanine at position 120 a
✍ Kazufumi Masuda; Keietsu Tamagake; Takashi Katsu; Fumihiro Torigoe; Keita Saito; πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 350 KB

## Abstract The roles of Phe‐120 and Glu‐222 in the oxidation of chiral substrates bunitrolol (BTL) and bufuralol (BF) by CYP2D6 are discussed. Wild‐type CYP2D6 (CYP2D6‐WT) oxidized BTL to 4‐hydroxybunitrolol (4‐OH‐BTL) with substrate enantioselectivity of (__R__)‐(+)‐BTL > (__S__)‐(βˆ’)‐BTL. The sam