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Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells

✍ Scribed by Dong-Jun Peng; Juan Wang; Jun-Ying Zhou; Gen Sheng Wu


Book ID
116300027
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
624 KB
Volume
394
Category
Article
ISSN
0006-291X

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## Abstract Resistance to cisplatin‐based chemotherapy is a major cause of treatment failure in human ovarian cancer. Wild‐type __TP53__ status is often, but not always, associated with cisplatin sensitivity, suggesting that additional factors may be involved. Overexpression/activation of the phosp