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Role of TAP-1 and/or TAP-2 antigen presentation defects in tumorigenicity of mouse melanoma

✍ Scribed by Shefali Agrawal; Keith Reemtsma; Emilia Bagiella; Soji F Oluwole; Ned S Braunstein


Book ID
113526778
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
546 KB
Volume
228
Category
Article
ISSN
0008-8749

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TAP1 and TAP2 molecules are involved in the transport of peptides prior to their association with class I molecules and are mandatory for efficient antigen presentation. To investigate whether loss of expression of TAP1 or TAP2 is a likely mechanism of immune escape in malignant melanoma, TAP1 and T