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Role of TAFII-17, a VDR Binding Protein, in the Increased Osteoclast Formation in Paget's Disease

โœ Scribed by Noriyoshi Kurihara; Sakamuri V Reddy; Norie Araki; Seiichi Ishizuka; Keiichi Ozono; Jillian Cornish; Tim Cundy; Frederick R Singer; G David Roodman


Book ID
111485076
Publisher
American Society for Bone and Mineral Research
Year
2004
Tongue
English
Weight
517 KB
Volume
19
Category
Article
ISSN
0884-0431

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The vitamin D receptor (VDR) elicits a transcriptional response to 1,25-dihydroxyvitamin D 3 by binding to specific response elements (VDRE) in the promoter of target genes. Retinoic X receptor (RXR) is required for formation of the VDR-VDRE complex when VDR is supplied at physiologic concentrations