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Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

✍ Scribed by Toshiaki Sendo; Yoshinori Itoh; Takeshi Goromaru; Toshio Hirakawa; Mawako Ishida; Hitoo Nakano; Ryozo Oishi

Book ID
116830443
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
78 KB
Volume
25
Category
Article
ISSN
0196-9781

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## Abstract We have previously shown that sensory nerve peptides contribute to the pathogenesis of pulmonary hypersensitivity reactions (HSRs) to paclitaxel in rats. Moreover, pemirolast, an antiallergic agent, reverses the HSRs to paclitaxel, although the mechanism is considered to result from the