𝔖 Bobbio Scriptorium
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Role of sterol carrier protein in cholesterol metabolism

✍ Scribed by Mary E. Dempsey; Pamela S. Hargis; Denise M. McGuire; Anne McMahon; Carol D. Olson; Lisa M. Salati; Steven D. Clarke; Howard C. Towle

Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
698 KB
Volume
38
Category
Article
ISSN
0009-3084

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✦ Synopsis

This report summarizes our recent studies on the protein known as steroi carrier protein (SCP) or fatty acid binding protein (FABP). SCP is a highly abundant, ubiquitous protein with multifunctional roles in the regulation of lipid metabolism and transport. SCP in vitro activates membrane-bound enzymes catalyzing cholesterol synthesis and metabolism, as well as those catalyzing long chain fatty acid metabolism. SCP also binds cholesterol and fatty acids with high affinity and rapidly penetrates cholesterol containing model membranes. Studies in vivo showed SCP undergoes a remarkable diurnal cycle in level and synthesis, induced by hormones and regulated in liver by translational events. SCP rapidly responds in rive to physiological events and manipulations affecting lipid metabolism by changes in level. Thus SCP appears to be an important regulator of lipid metabolism. Preliminary evidence is presented that SCP is secreted by liver and intestine into blood and then taken up by tissues requiring SCP but incapable of adequate SCP synthesis.

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