Role of spectral presaturation attenuated inversion-recovery fat-suppressed T2-weighted MR imaging in active inflammatory bowel disease
✍ Scribed by Unni K. Udayasankar; Diego Martin; Thomas Lauenstein; Robin Rutherford; John Galloway; Dana Tudorascu; Shanthi V. Sitaraman
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 182 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose
To retrospectively evaluate the efficacy of spectral presaturation attenuated inversion‐recovery (SPAIR) fat‐suppressed (FS) partial Fourier single shot (SSH) T2‐weighted (T2W) and gadolinium‐enhanced (Gd) FS 3D‐gradient echo (3DGRE) T1‐weighted (T1W) delayed phase MRI to differentiate active bowel inflammation from fibrotic disease in patients with Crohn's disease (CD).
Materials and Methods
MRI studies of 81 patients (mean age, 43 years; range, 22–77 years; M:F ratio 33:48) had T2W and T1W imaging including SPAIR‐SSH and delayed Gd‐3DGRE. The ability to assess disease activity in bowel segments affected were retrospectively evaluated by a grading scheme based on subjective analysis of signal intensities. These results were compared against the standard clinical parameters of disease activity.
Results
SPAIR‐SSH images correlated better (r = 0.74, P < 0.0001) with activity than delayed Gd‐3DGRE (r = 0.39, P = 0.0003), with a significant difference between the two techniques (P < 0.0001). SPAIR‐SSH images showed higher specificity in detection of severely active disease in per patient (98%) and segmental (98%) analysis compared to Gd‐3DGRE (57%, 70%). Gd‐3DGRE technique showed significantly higher sensitivity (P = 0.01) in identifying active disease in per patient (83%) and segmental (85%) analysis compared to SPAIR‐SSH (70%, 64%).
Conclusion
SPAIR‐SSH detects actively diseased CD bowel segments with a high level of specificity. Noninflammatory bowel fibrosis corresponds to abnormal uptake on delayed phase Gd‐3DGRE images but without associated elevated abnormal signal on SPAIR‐SSH. J. Magn. Reson. Imaging 2008;28:1133–1140. © 2008 Wiley‐Liss, Inc.