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Role of solution conformation and flexibility of short peptide ligands that bind to the p56lck SH2 domain

✍ Scribed by Frank J Dekker; Nico J de Mol; Patrick Bultinck; Johan Kemmink; Hans W Hilbers; Rob M.J Liskamp

Book ID: 108479283
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 321 KB
Volume: 11
Category: Article
ISSN: 0968-0896
DOI: 10.1016/s0968-0896(02)00536-9

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## Abstract A frequently used approach to transform peptides into more drug‐like compounds is preparation of the corresponding peptoids or peptide–peptoid hybrids. Although peptoids have advantages, there may also be some disadvantages such as their increased flexibility and the reduced ability for