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Role of soluble adenylyl cyclase in mitochondria

✍ Scribed by Valsecchi, Federica; Konrad, Csaba; Manfredi, Giovanni

Book ID: 124130228
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 821 KB
Volume: 1842
Category: Article
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2014.05.035

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## Abstract High ${\rm [HCO}\_3^ - ]$ inhibits and low ${\rm [HCO}\_3^ - ]$ stimulates bone resorption, which mediates part of the effect of chronic acidosis or acid feeding on bone. Soluble adenylyl cyclase (sAC) is a bicarbonate sensor that can potentially mediate the effect of bicarbonate on ost