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Role of recombinant mitogen-activated protein kinases JNK and p38 in the regulation of apoptosis in blood mononuclear cells under conditions of oxidative stressin vitro

✍ Scribed by N. V. Ryazantseva; V. V. Novitsky; N. Yu. Chasovskih; E. V. Kaygorodova; E. G. Starikova; Yu. V. Starikov; T. T. Radzivil

Publisher: Springer US
Year: 2008
Tongue: English
Weight: 242 KB
Volume: 145
Category: Article
ISSN: 0007-4888
DOI: 10.1007/s10517-008-0145-z

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi