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Role of Raf-1 Conserved Region 2 in Regulation of Ras-Dependent Raf-1 Activation

✍ Scribed by Hiroyoshi Sendoh; Chang-Deng Hu; Dongmei Wu; Chunhua Song; Yuriko Yamawaki-Kataoka; Joji Kotani; Tomoyo Okada; Fumi Shima; Ken-ichi Kariya; Tohru Kataoka

Book ID
115585760
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
180 KB
Volume
271
Category
Article
ISSN
0006-291X

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Mutations in conserved regions 1, 2, and
Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity
✍ Edmond Y. W. Chan; Stacey L. Stang; Drell A. Bottorff; James C. Stone πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 136 KB

## Abstract To investigate the role of Raf‐1 in v‐Ha‐ras transformation, we have isolated and characterized a number of Raf‐1 mutants that display increased transforming activity in Rat2 fibroblasts. A dipeptide deletion (Ξ”144–145) in the cysteine‐rich domain (CRD) of conserved region (CR) 1 increa