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Role of radiotherapy in early glottic carcinoma

✍ Scribed by Robert I. Smee; Nicola S. Meagher; Janet R. Williams; Kathryn Broadley; G. Patrick Bridger

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 402 KB
Volume: 32
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21262

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Early glottic carcinoma has a high local control prospect with radiotherapy. This review evaluates a single center's experience.

Methods

All patients from 1967 to 2006 diagnosed with Tis/T1/T2/N0 early glottic carcinoma treated definitively with radiotherapy at Prince of Wales Hospital were reviewed. Local control and cancer‐specific survival (CSS) rates were primary endpoints, and the impact of various factors on these outcomes was statistically analyzed.

Results

This review of 522 patients includes 24 with Tis, 356 with T1, and 142 with T2. Ultimate local control rates were as follows: Tis 87.5%, T1 94.7%, and T2 84.5%. Multivariate analysis found fitness for surgery, no involvement of anterior commissure, normal cord movement, and radiotherapy dose >60 Gy significant for local control. Fitness for surgery, no involvement of the anterior commissure, normal cord movement, and no ventricular involvement were significant prognostic factors for CSS.

Conclusion

Definitive radiotherapy for early glottic carcinoma provides high local control rates, with the option of surgical salvage to achieve ultimate local control. © 2009 Wiley Periodicals, Inc. Head Neck, 2010

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