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Role of radionuclide studies in drug development and evaluation

✍ Scribed by Strauss, H.William; Fischman, Alan J; Rubin, Robert


Book ID
123327727
Publisher
Elsevier Science
Year
1992
Weight
86 KB
Volume
19
Category
Article
ISSN
0883-2897

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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t