✦ LIBER ✦

Role of radioimmunolocalization in the staging of gastric carcinoma

✍ Scribed by Antonio Mussa; Sergio Sandrucci; Alberto Mobiglia; Massimo Baccega; Baudolino Mussa; Pier Giuseppe De Filippi

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 28 KB
Volume: 15
Category: Article
ISSN: 8756-0437
DOI: 10.1002/(sici)1098-2388(199812)15:4<209::aid-ssu3>3.0.co;2-d

No coin nor oath required. For personal study only.

✦ Synopsis

Intraoperative radioimmunolocalization is a potentially useful technique for staging gastric neoplasms without resorting to extensive surgical intervention. Before preoperative immunohistochemical typing for the presence or absence of tumor-associated glycoprotein (TAG) 72, we performed intraoperative radioimmunodetection on three patients presenting with gastric carcinoma using a whole monoclonal antibody (B72.3) marked with Indium-111 injected 1 week before operation. The results were calculated on the number of lymph node stations and yielded a high sensitivity due to a specificity of 72% and the absence of false negatives. Intraoperative radioimmunolocalization is a promising method for noninvasive staging of both early and advanced gastric carcinoma.

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