Paradoxical role of apoptosis in tumor p
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Katerina V. Gurova; Andrei V. Gudkov
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Article
📅
2002
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John Wiley and Sons
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English
⚖ 255 KB
## Abstract Tumors frequently acquire resistance to apoptosis that is expected to contribute to malignant phenotype and reduce sensitivity to treatment. In fact, inactivation of __p53__ tumor suppressor gene resulting in suppression of apoptosis serves as a negative prognostic marker. Surprisingly,