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Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIα expression☆

✍ Scribed by Leonardo Salmena; Viengthong Lam; J Peter McPherson; Gerald J Goldenberg

Book ID
113992618
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
509 KB
Volume
61
Category
Article
ISSN
0006-2952

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The glucose-regulated stress response of cancer cells leads to a decreased expression of DNA topoisomerase IIalpha (topo IIalpha) and a cell cycle arrest at the G1 phase. In this study, we found that the topo IIalpha decrease occurred specifically during the G1 arrest in human colon adenocarcinoma H