A 2A adenosine receptors are expressed on immune cells including neutrophils, lymphocytes, eosinophils, monocytes/macrophages, and mast cells. Activation of A 2A receptors on these cells stimulates an increase in [cyclic AMP] i and causes a diminution of inflammatory responses. In mast cells, degran
Role of protease-activated receptor 2 in joint inflammation
β Scribed by Francis F. Y. Lam
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 44 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0004-3591
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## Abstract Protease activated receptor 2 (PAR2) is widelyβdistributed (lung, liver, kidney, etc.) and expressed by variety of cells (i.e. leukocytes, epithelial cells, endothelial cells, and fibroblast). PAR2 may participate in many pathological processes, such as, inflammation, injury, as well as
## Abstract ## Objective To investigate the role of proteinaseβactivated receptor 4 (PARβ4) in mediating joint inflammation and pain in mice. ## Methods Knee joint blood flow, edema, and pain sensitivity (as induced by thermal and mechanical stimuli) were assessed in C57BL/6 mice following intra