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Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury

✍ Scribed by Yutaka Komatsu; Yasushi Shiratori; Yohko Hikiba; Naoaki Hashimoto; Katsuken Han; Tateo Kawase; Haruhiko Yoshida; Ken'ichi Okano; Masao Omata


Publisher
Springer US
Year
1996
Tongue
English
Weight
981 KB
Volume
41
Category
Article
ISSN
0163-2116

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Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe