Role of physiology in the determination of protein heterogeneity

✍ Scribed by Nigel Jenkins

• Book ID: 104361905
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 470 KB
• Volume: 7
• Category: Article
• ISSN: 0958-1669
• DOI: 10.1016/s0958-1669(96)80014-0

✦ Synopsis

One of the major problems faced in the manufacture of recombinant proteins is the assessment and control of product heterogeneity, which is caused mainly by the biological variation in post-translational processing. The past year has witnessed significant improvements both in analytical methods for detecting variation in this processing and in our ability to control it.