Role of phospholipase A2 in prepulse inhibition of the auditory startle reflex in rats
β Scribed by Li-Yen Lee; Akhlaq A. Farooqui; Gavin S. Dawe; Jean-Marc Burgunder; Wei-Yi Ong
- Book ID
- 116771167
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 245 KB
- Volume
- 453
- Category
- Article
- ISSN
- 0304-3940
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## Abstract We tested the hypothesis that glutamate transporter GLTβ1 (also known as EAAT2) plays a role in the regulation of prepulse inhibition (PPI) of the acoustic startle reflex, a simple form of information processing which is reduced in schizophrenia. To do this, we studied PPI in rats treat
Prepulse inhibition (PPI) is the attenuation of the startle reflex when the sudden intense startling stimulus is shortly preceded by a weaker, non-startling sensory stimulus (prepulse). PPI reflects a protective function of reducing disruptive influences to the processing of prepulse signals and is