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Role of Phenoxyl Radicals in DNA Adduction by Chlorophenol Xenobiotics Following Peroxidase Activation

โœ Scribed by Dai, Jian; Sloat, Amy L.; Wright, Marcus W.; Manderville, Richard A.


Book ID
127239092
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
209 KB
Volume
18
Category
Article
ISSN
0893-228X

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## Abstract Foodโ€derived heterocyclic aromatic amines (HCAs) have proved to be carcinogenic in both rodents and nonhuman primates. Two different metabolic pathways are suggested for the metabolic activation of HCA. The hepatic pathway proceeds via a twoโ€step process involving __N__โ€hydroxylation by