Role of PEPT2 in the Choroid Plexus Uptake of Glycylsarcosine and 5-Aminolevulinic Acid: Studies in Wild-Type and Null Mice
β Scribed by Scott M. Ocheltree; Hong Shen; Yongjun Hu; Jianming Xiang; Richard F. Keep; David E. Smith
- Book ID
- 111603704
- Publisher
- Springer US
- Year
- 2004
- Tongue
- English
- Weight
- 135 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0724-8741
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The purpose of this study was to determine the relative importance of peptide transporter 1 (PEPT1) in the uptake of peptides/mimetics from mouse small intestine, using glycylsarcosine (GlySar). After isolating jejunal tissue from wild-type and Pept1 null mice, 2 cm intestinal segments were everted
## Abstract Human cystatin C (HCC) is one of the amyloidogenic proteins to be shown to oligomerize via a threeβdimensional domain swapping mechanism. This process precedes the formation of a stable dimer and proceeds particularly easily in the case of the L68Q mutant. According to the proposed mech