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Role of PDE3 and PDE4 for β-adrenergic control of cAMP and ICa,L in adult rat ventricular myocytes

✍ Scribed by Jérôme Leroy; Aniella Abi-Gerges; Wito Richter; Viacheslav O. Nikolaev; Stefan Engelhardt; Martin J. Lohse; Marco Conti; Rodolphe Fischmeister; Grégoire Vandecasteele


Book ID
116984701
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
53 KB
Volume
42
Category
Article
ISSN
0022-2828

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## Abstract We have shown that the stimulation of β‐adrenergic receptors (β‐AR) increases apoptosis in adult rat ventricular myocytes (ARVMs). Integrins, a family of αβ‐heterodimeric cell surface receptors, are postulated to play a role in ventricular remodeling. Here, we show that norepinephrine (