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Role of parathyroid hormone in the pathogenesis of the uremic manifestations

โœ Scribed by Massry, S. G.


Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
408 KB
Volume
57
Category
Article
ISSN
1432-1440

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Polymorphonuclear leukocytes (PMNLs) from uremic patients have elevated basal levels of cytosolic calcium ([Ca2+]i), reduced calcium signal after activation of Fc(gamma) RIII receptor, and impaired phagocytosis. Chronic excess of parathyroid hormone (PTH) in uremia mediates its effect on PMNL's meta