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Role of P-glycoprotein in colchicine and vinblastine cellular kinetics in an immortalized rat brain microvessel endothelial cell line

✍ Scribed by Bouchra El Hafny; Nathalie Cano; Michèle Pidotti; Anthony Regina; Jean-Michel Scherrmann; Françoise Roux


Book ID
119407291
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
975 KB
Volume
53
Category
Article
ISSN
0006-2952

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## Abstract A major concern regarding the chronic administration of antiretroviral drugs is the potential for induction of drug efflux transporter expression (i.e., P‐glycoprotein, P‐gp) at tissue sites that can significantly affect drug distribution and treatment efficacy. Previous data have shown