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Role of oxidative stress and nitric oxide in the protective effects of α-lipoic acid and aminoguanidine against isoniazid–rifampicin-induced hepatotoxicity in rats

✍ Scribed by Evan I. Saad; Sahar M. El-Gowilly; Mabrouka O. Sherhaa; Azza E. Bistawroos

Book ID
116463330
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
449 KB
Volume
48
Category
Article
ISSN
0278-6915

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## Abstract Oral administration of a‐lipoic acid, a metavitamin, was investigated for its possible hepatoprotective effect in Wistar rats against chloroquine‐induced toxicity. Rats were treated orally with __α__‐lipoic acid (10, 30 and 100 mg kg^−1^ day^−1^) for 7 days before a single oral administ