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✦   LIBER   ✦

Role of Oct-6 in Schwann cell differentiation

✍ Scribed by Meijer, Dies; Jaegle, Martine

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
265 KB
Volume
41
Category
Article
ISSN
1059-910X

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✦ Synopsis

Research into the POU transcription factor Oct-6 has been the focus of much current attention, in particular its role in Schwann cell development and differentiation. Based on published data and data presented here, we propose a model for Oct-6 function at two distinct stages of Schwann cell maturation. First, Oct-6 function is required in promyelin cells for their timely differentiation into myelinating cells. Second, Oct-6 functions during myelination and is required for the proper downregulation of its own gene. While the first function of Oct-6 is firmly established, the second function is still highly hypothetical. Experiments to establish a distinct role for Oct-6 in late Schwann cell differentiation are discussed.

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