Contribution of O6-methylguanine-DNA met
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Michael S. Bobola; Mitchel S. Berger; John R. Silber
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Article
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1995
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John Wiley and Sons
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English
⚖ 711 KB
## Abstract To assess the possible role of the DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) in resistance of brain neoplasms to the clinically important chloroethylating agent 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU), we quantitated MGMT activity, BCNU survival, and the