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Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein

✍ Scribed by Lewis, Martin D; Roberts, Ben J


Book ID
110067776
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
248 KB
Volume
22
Category
Article
ISSN
0950-9232

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MUTATION OF THE VON HIPPEL-LINDAU TUMOUR
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A series of 20 capillary haemangioblastomas of the central nervous system was screened for mutations of the von Hippel-Lindau ( VHL) tumour suppressor gene by single strand conformational polymorphism (SSCP) and heteroduplex analysis. Aberrant polymerase chain reaction (PCR) products were detected i

Improved detection of germline mutations
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Communicated by Victor A. McKusick von Hippel-Lindau disease (VHL) is an inherited neoplastic disorder characterized by the development of tumors in the eyes, brain, spinal cord, inner ear, adrenal gland, pancreas, kidney, and epididymis. The VHL tumor suppressor gene was identified in 1993. Initial