Role of NK and T cells in IL-12-induced anti-tumor response against hepatic colon carcinoma

Anti-CD30-IL-12 antibody-cytokine fusion

Anti-CD30-IL-12 antibody-cytokine fusion protein that induces IFN-γ secretion of T cells and NK cell-mediated lysis of Hodgkin's lymphoma-derived tumor cells

✍ Claudia Heuser; Volker Diehl; Hinrich Abken; Andreas Hombach 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 153 KB

## Abstract Interleukin‐12 (IL‐12) is a disulfide‐linked p40‐p35 heterodimeric cytokine and plays a key role in linking innate cellular immunity to an adaptive Th1 response against pathogens and tumor cells and in counteracting a Th2 immune response. The pathogenesis of Hodgkin's disease (HD) is pa