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Role of nitric oxide and melanogenesis in the accomplishment of anticryptococcal activity by the BV-2 microglial cell line

✍ Scribed by Elisabetta Blasi; Roberta Barluzzi; Rosanna Mazzolla; Brunella Tancini; Silvia Saleppico; Manuela Puliti; Lucia Pitzurra; Francesco Bistoni


Book ID
119109241
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
595 KB
Volume
58
Category
Article
ISSN
0165-5728

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This study demonstrates that cyclic AMP (cAMP) production is induced by lipopolysaccharide (LPS) stimulation and activates two different pathways in murine BV2 microglial cells. Two principal effector proteins for cAMP are protein kinase A (PKA) and cAMP-responsive guanine nucleotide exchange factor