Role of NF-κB activation and nitric oxide expression during PGE1 protection against d-galactosamine-induced cell death in cultured rat hepatocytes

PGE1-induced NO reduces apoptosis by D-g

PGE1-induced NO reduces apoptosis by D-galactosamine through attenuation of NF-κB and NOS-2 expression in rat hepatocytes

✍ Emilio Siendones; Dalia Fouad; María José M. Díaz-Guerra; Manuel de la Mata; Lis 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB

Prostaglandin E 1 (PGE 1 ) reduces cell death in experimental and clinical liver dysfunction. We have previously shown that PGE 1 preadministration protects against NO-dependent cell death induced by D-galactosamine (D-GalN) through a rapid increase of nuclear factor B (NF-B) activity, inducible NO