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Role of Network Branching in Eliciting Differential Short-Term Signaling Responses in the Hypersensitive Epidermal Growth Factor Receptor Mutants Implicated in Lung Cancer

✍ Scribed by Jeremy Purvis; Vibitha Ilango; Ravi Radhakrishnan

Book ID: 109387768
Publisher: American Institute of Chemical Engineers
Year: 2008
Tongue: English
Weight: 582 KB
Volume: 24
Category: Article
ISSN: 8756-7938
DOI: 10.1021/bp070405o

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## Abstract The high frequency of epidermal growth factor receptor (__EGFR__) mutations in tyrosine kinase inhibitor‐responsive non‐small‐cell lung cancer (NSCLC) cases is now well established, highlighting the predictive value of activating __EGFR__ mutations in guiding the clinical use of __EGFR_