๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance

โœ Scribed by G. R. Jackson; L. Apffel; K. Werrbach-Perez; J. R. Perez-Polo

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
803 KB
Volume
25
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

โœฆ Synopsis

The nerve growth factor protein (NGF) regulates neuronal cell death during the development of embryonic sensory and sympathetic neurons in the peripheral nervous system (PNS). NGF protects the rat pheochromocytoma line PC12, a useful model of NGF responsive peripheral neurons, from hydrogen peroxide, which interacts with ferrous iron to generate hydroxyl radicals. Exogenous catalase provides protection, whereas superoxide dismutase (SOD) has no effect on neuronal survival when PC12 cells are challenged with hydrogen peroxide. NGF treatment of PC12 cells increases the activity of catalase. NGF protection from hydrogen peroxide is partially abolished by aminotriazole (Az), a low molecular weight catalase inhibitor. Taken together, these data are consistent with the hypothesis that NGF protects from peroxidative events and consequent cell death via an induction of free radical detoxifying mechanisms, such as catalase activity.

๐Ÿ“œ SIMILAR VOLUMES

Role of nerve growth factor in oxidant-a
Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. II. A conditioning lesion paradigm
โœ G. R. Jackson; K. Werrbach-Perez; J. R. Perez-Polo ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 567 KB

The PC12 rat pheochromocytoma cell line is a nerve growth factor (NGF) responsive line that is protected by NGF from the toxic effects of hydrogen peroxide induced peroxidation. In part, NGF protection of PC12 cells acts through a shift in oxidant-antioxidant metabolism by the enhancement of catalas

Role of nerve growth factor in the adult
Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury
โœ Keith M. Rich; Henry K. Yip; Patricia A. Osborne; Robert E. Schmidt; Eugene M. J ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 1000 KB

## Abstract The response of dorsal root ganglia (DRG) neurons to NGF deprivation and to axotomy was examined in adult guinea pigs. The success of NGF deprivation by means of an autoimmune approach was monitored by the measurement of serum antibody titer levels against guinea pig NGF with the standa