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Role of Na+, K+-ATPase α1 subunit in the intracellular accumulation of cisplatin

✍ Scribed by Shuichi Kishimoto; Yuji Kawazoe; Mako Ikeno; Mizuha Saitoh; Yukari Nakano; Yuko Nishi; Shoji Fukushima; Yoshikazu Takeuchi

Publisher
Springer
Year
2005
Tongue
English
Weight
301 KB
Volume
57
Category
Article
ISSN
0344-5704

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✍ Gang Wang; Kiyoshi Kawakami; Gregory Gick 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB

## Abstract Na,K‐ATPase expression is upregulated in mammalian cells as a consequence of persistent inhibition of Na,K‐ATPase enzymatic activity by low external K^+^. We previously demonstrated that exposure of neonatal rat cardiac myocytes to low K^+^ increased Na,K‐ATPase α1 subunit mRNA content