Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1–mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells

Increase of nuclear phosphatidylinositol

Increase of nuclear phosphatidylinositol 4,5-bisphosphate and phospholipase C β1 is not associated to variations of protein kinase C in multidrug-resistant Saos-2 cells

✍ Zini, Nicoletta; Neri, Lucam M.; Ognibene, Andrea; Scotlandi, Katia; Baldini, Ni 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB

The multidrug resistance (MDR) phenotype that is mediated by an overexpression of P-glycoprotein, has been suggested to be related also to an increased activity of protein kinase C (PKC) and to changes in phospholipid pattern. By electron microscope quantitative immunocytochemistry, we investigated