Role of mouse germ-cell mutagenesis in understanding genetic risk and in generating mutations that are prime tools for studies in modern biology
✍ Scribed by Liane B. Russell
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 727 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0893-6692
No coin nor oath required. For personal study only.
✦ Synopsis
Biology Division, Oak Ridge National laboratory, Oak Ridge, Tennessee --Highlights are presented on ( 1 ) the role mouse genic mutations and one for deletions and other germ-cell mutagenesis has played in assessing rearrangements, have become very useful in the the genetic harm from radiations and chemicals, manufacture of mutations for specific purposes.
and
(2) the contributions to the field of modern
The mutations propagated from radiationbiology that are being made by the products of and chemical-mutogenesis experiments are this research-the propagated mutations. providing prime resources for basic studies in Among the numerous findings in radiation mu-genome organization, gene structure, and functagenesis were the humped dose-effect curve tion. DNA lesions that involve specific loci have for spermatogonial stem cells, the major differ-made possible increasingly detailed characterences between the sexes and between germ-cell ization of extensive deletion complexes that fastages of each sex in both yield and nature of cilitate high-intensity physical and functional mutations, the dose-rate effect, which provided mapping within them. Numerous loci associated the first evidence for repair of mutational (or with interesting developmental anomalies have premutotional) damage, the augmenting effect been identified and have become accessible to of certain regimes of dose fractionation, and positional cloning. Several of the genes acmany others. Chemicol mutagenesis studies that cessed with the aid of induced mutations (delefollowed revealed at least three patterns of mu-tions, other rearrangements, and point mutatation yield and demonstrated that germ-cell tions) are furnishing prime reagents for stage-much more than the nature of the chemi-elucidating human disease conditions. col-governs the nature of the DNA lesions in-