Role of mitochondrial dysfunction in Alzheimer's disease

✍ Scribed by Rudy Castellani; Keisuke Hirai; Gjumrakch Aliev; Kelly L. Drew; Akihiko Nunomura; Atsushi Takeda; Adam D. Cash; Mark E. Obrenovich; George Perry; Mark A. Smith

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 283 KB
• Volume: 70
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.10389

✦ Synopsis

Abstract

Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease. © 2002 Wiley‐Liss, Inc.