𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells

✍ Scribed by A. Kallio; A. Zheng; J. Dahllund; K. M. Heiskanen; P. Härkönen


Publisher
Springer
Year
2005
Tongue
English
Weight
762 KB
Volume
10
Category
Article
ISSN
1360-8185

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


RNAi-mediated silencing of insulin recep
✍ Gregory Cesarone; Cecilia Garofalo; Marc T. Abrams; Olga Igoucheva; Vitali Alexe 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB

## Abstract Insulin receptor substrate 1 (IRS‐1) is a major downstream signaling protein for insulin and insulin‐like growth factor I (IGF‐I) receptors, conveying signals to PI‐3K/Akt and ERK1/2 pathways. In breast cancer, IRS‐1 overexpression has been associated with tumor development, hormone‐ind

Tamoxifen induces selective membrane ass
✍ Yaakov Lavie; Zu-chuan Zhang; Hui-ting Cao; Tie-Yan Han; Ralph C. Jones; Yong-Yu 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 134 KB 👁 2 views

Tamoxifen, a synthetic antiestrogen, is known for its antitumoral action in vivo; however, it is well accepted that many tamoxifen effects are elicited via estrogen receptor-independent routes. Previously, we reported that tamoxifen induces PKC translocation in fibroblasts. In the present study, we

Tamoxifen induces TGF-β1 activity and ap
✍ Hongmin Chen; Thomas R. Tritton; Nicholas Kenny; Marlene Absher; Jen-Fu Chiu 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 882 KB

We report here that the antiestrogen tamoxifen (TAM) induces cell death in human breast cancer cell line MCF-7. We assessed the type of cell death induced by TAM in this breast cancer cell line on the basis of morphological and biochemical characteristics. Dying cells showed morphological characteri

Rapid onset of nucleolar disintegration
✍ Jacek Wojciechowski; Marcel Horky; Marieta Gueorguieva; Józefa Węsierska-Gądek 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 818 KB

## Abstract The aim of our study was to explore the antiproliferative and pro‐apoptotic action of roscovitine (ROSC) on human breast cancer MCF‐7 cells. We examined the effect of ROSC on cell proliferation, cell cycle progression, nucleolar morphology, posttranslational modifications of histones as

Modulatory effect of tamoxifen and ICI 1
✍ Rosa De Vincenzo; Giovanni Scambia; Pierluigi Benedetti Panici; Andrea Fattoross 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 865 KB

In this study the ability of the new pure anti-estrogen IcI 182,780 to modulate the cytotoxic action of adriamycin (ADR) on parental and ADR-resistant MCF-7 (MCF-7 ADRr) human breast-cancer cells was investigated and compared with that of tamoxifen (TAM). TAM enhanced ADR cytotoxicity in MCF-7 ADRr