Role of Metals in the Reaction Catalyzed by Protein Farnesyltransferase †
✍ Scribed by Saderholm, Matthew J.; Hightower, Kendra E.; Fierke, Carol A.
- Book ID
- 126956042
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 84 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0006-2960
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A variety of compounds that show promise in cancer chemotherapy and chemoprevention have been identified as farnesyltransferase inhibitors. These can be classified into mainly two different types of inhibitors, farnesyl diphosphate competitors and CAAX peptidomimetics. The former type acts by compet
## Abstract To investigate the influence of the 5‐thioether moiety of our previously identified hit thiophene compound upon protein farnesyltransferase inhibition, we synthesized a new library of 3‐(4‐chlorophenyl)‐4‐cyanothiophene‐2‐carboxylic derivatives through the application of aromatic nucleo