𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Role of Metals in the Reaction Catalyzed by Protein Farnesyltransferase †

✍ Scribed by Saderholm, Matthew J.; Hightower, Kendra E.; Fierke, Carol A.


Book ID
126956042
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
84 KB
Volume
39
Category
Article
ISSN
0006-2960

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Advances in the development of farnesylt
✍ Wenli Yang; Keith Del Villar; Jun Urano; Hiroshi Mitsuzawa; Fuyuhiko Tamanoi 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

A variety of compounds that show promise in cancer chemotherapy and chemoprevention have been identified as farnesyltransferase inhibitors. These can be classified into mainly two different types of inhibitors, farnesyl diphosphate competitors and CAAX peptidomimetics. The former type acts by compet

SNAr and Palladium-Catalyzed Reactions o
✍ Sébastien Lethu; Joëlle Dubois 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 525 KB

## Abstract To investigate the influence of the 5‐thioether moiety of our previously identified hit thiophene compound upon protein farnesyltransferase inhibition, we synthesized a new library of 3‐(4‐chlorophenyl)‐4‐cyanothiophene‐2‐carboxylic derivatives through the application of aromatic nucleo