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Role of messenger RNA subcellular localization in the posttranscriptional regulation of human histone gene expression

✍ Scribed by G. Zambetti; J. Stein; G. Stein

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
807 KB
Volume
144
Category
Article
ISSN
0021-9541

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✦ Synopsis

Histone mRNAs are naturally localized on non-membrane-bound polysomes and selectively destabilized during inhibition of DNA replication. Targeting histone mRNA to membrane-bound polysomes, by incorporating sequences coding for a signal peptide into the message, results in the stabilization of the histone fusion mRNA when DNA synthesis is interrupted (Zambetti et at.: Proceedings of the

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